Means for treatment of blood with oxygen or ozone and ultraviolet light



May 19, 1959 w R 2,887,107

MEANS FOR TREATMENT OF BLOOD WITH OXYGEN OR OZONE AND ULTRAVIOLET LIGHT Filed June 28, 1954 3 Sheets-Sheet 1 2,887,107 GEN OR F. WEHRLI May 19, '1959 MEANS FOR TREATMENT OF BLOOD WITH OXY OZONE AND ULTRAVIOLET LIGHT 5 Sheets-Sheet 2 Filed June 28. 1954 3 Sheets-Sheet 3 F. WEHRLI F BLOOD WITH OXYGEN OR OZONE AND ULTRAVIOLET LIGHT MEANS FOR TREATMENT O 3 49 n m m M n H w.

i f v Q A. e n I I WT u. 111:; U mmflmfimmmwww%%www i Al d II M .llz 9 a 5 3 l 2 7 May 19, 1959 Filed June 28, 1954 FOR TREATMENT OF BLOOD WITH OXY- GEN OR OZONE AND ULTRAVIOLET LIGHT Ihe present invention relates to the treatment of blood with oxygen or ozone and ultraviolet light, and to an apparatus for this purpose.

. It is a main object of the invention to bring the blood in particularly close contact with the oxygen or. ozone.

It is another main object of the invention to subject the blood to a thorough irradiation by ultraviolet light. It is yet another object of the invention to prevent at will the mixing of the blood treated with blood yet untreated.

It is still another object of the invention to provide the possibility of circulation of the blood through the oxidizing and, irradiation treatment, either from the outlet of the apparatus back to its inlet, or from the patient through the apparatus and back to the patient.

With these and other objects in view my improved apparatus for the oxidizing treatment of blood provides for introducing an oxidizing gas of the group consisting of oxygen and ozone into the blood, forming a foam of the blood and the said oxidizing gas, passing the said foam in a thin layer through ultraviolet radiation, and collecting the oxidized and irradiated blood as a liquid.

Preferably the said thin foam layer is allowed to purl over a sloping surface exposed to the said ultraviolet radiation, and preferably the blood is kept in motion by the action of the said oxidizing gas after having been collected as a liquid.

By the formation of foam a most intimate contact between the blood and the oxidizing gas is established whereby a thorough oxidation of the blood is eliected, and by passing the blood foam in a thin layer through ultraviolet radiation too far reaching an absorption of said radiation by too thick a layer is obviated, and the danger that blood particles too far remote from the source?-ofxultraviolet radiation'mayremain without irradiation is thereby avoided. t

Theseand other objects and features of my said invention will be clearly understood from the following description of a preferred embodiment of my improved apparatus, given by way of example with reference to the accompanying drawings, in which:

Figs. 1 and 2 are diagrammatic perspective views of the general arrangement of the apparatus for the treatment and dispensing of blood after the same has been treated,

Fig. 3 shows the apparatus for the treatment of the blood in a vertical section on a larger scale, and

Fig. 4 is a section along the line III-III of Fig. 3.

On a movable talble two compressed gas bottles 2 are arranged under the table top, which contain the oxygen or ozone to be introduced into the blood which has to be treated with ultraviolet rays. The oxygen or ozone is passed from the bottles 2 via a reduction valve 2a, pipe 31, pressure gauge 30 and pipe 32 into the upright pipes 3 through which it can arrive at the discharge sockets 3a and to the rubber hoses 3b. The provision of two bottles has the purpose of always having a spare bottle handy.

On the uprights 3 mounted on the table (in the embodi- United States Patent A 2,887,107 Patented May 19, 1959 5 the uprights 3 e.g. over his arm, and adjusted in height.

One of the said devices 4 is illustrated in a vertical section in Fig. 3. This device comprises two vessels 5, 6 arranged side by sideand atleast partly fused together, one of which, 5, serves for receiving the untreated blood, while the other vessel, 6, serves to store the treated blood. A pipe 7, through which the untreated blood enters, issues into the vessel 5. A socket 8, into which a non-return or excess pressure valve 9 is.-built, is connected to a pipe 3b (Fig. 1) coming from the oxygen or ozone bottles 2. Anormally closed drain" is denoted 10. In the interior of the vessel 5 a narrow vertical tube or raiser pipe 11 is arranged which flares out. at its upper end in the shape of a funnel 12. This raiser pipe 11 penetrates through a sloping plate 13 which is supported at 14 on brackets at the inner wall surface of the vessel 5 and extends into the vessel 6. The said raiser pipe 11 can for example be fused into one piece with the said plate 13.. At least one projection 15 prevents the plate 13 from sliding olf.

The vessel 6 isprovided at its lower end with a discharge socket 16 from whicha rubber hose 17 (Fig. 1) is passed to the patient. Into this rubber hose or into the vessel 6 oxygen can be passed, if desired, whereby the blood treated is constantly kept in motion and settling.

of theblood is thus prevented. To the hose 17 a tourniquet 18, a drop counter 19, a glass grain filter 20, an air' valve 21 and a vein-needle 22 are connected in series.

Above the two vessels 5 and 6, both of which are pro-' vided with scales 23 indicating their content, a hood 24,

the outer Wall of the vessels 5, 6 a filling 28 of sterilized gauze is provided which occupies the space 29 and prevents the penetration of aerobic spores from the atmospheric air] The same object could naturally be attained alternatively by a ground-in lid. Moreover, the burner may be used as a separate component of the apparatus, i.e. Without a fixed, connection with the quartz hood 26, so that this hood, equipped with an appropriate downward seal, could effect the screening against the ambient atmosphere.

The apparatus described operates as follows:

Untreated blood or even blood plasma is introduced through the pipe 7 into the vessel 5, the'usual pressure reducing valve 2a of the bottle 2 in actual use (Fig. 1) is opened, and oxygen or ozone is introduced through the socket 8 from the tapping socket 3a. lln the raiser pipe 11 (Fig. 3) which ends at a distance from and is thereby in communication with the lower end of the vessel 5, and accordingly fills in its lower part likewise with blood, the latter is mixed with oxygen or ozone, whereby foam bubbles are formed and a practically complete saturation with oxygen is established. From the flaring upper end 12 the blood foam emerges, which is then irradiated and sterilized by the ultraviolet ray emitter as the case may be. The ultraviolet ray emitter is a low pressure burner which practically develops near to no heat and has a radiation range from 1800 to 2600 Angstrom. The blood foam treated drips then ofi the plate 13 into the vessel 6 where it collapses again into liquid blood. The oxygen or ozone can escape through a pipe (not shown) connected to a socket 7a of the vessel 6, which is likewise protected by sterilized gauze 55 from the access of air. The device described permits circulation of the blood. The same can then after dis charge from the socket 16 be introduced again as often as desired .through .the pipe 7 into the vessel 5, and its treatment accordingly repeated.

As shown in Fig. 1, two such devices 4 are arranged on one and the same table 1 in order that no interruption in the treatment may occur even in the case of accldents.

In the hood 24, 26 (Fig. 3) for example additional oxygen inlets directed against the said blood foam generated by oxidizing gas introduced into the blood, may be provided in order to prevent an excessive formation of foam.

If desired, a pump or the hke (not shown) may be provided in order to bring the blood in a closed circuit from the vessel 6 through the patients body and again back into the vessel 5. Thereby it is made possible to normalize or to increase the oxygen quota.

In an analogous manner it is possible, to return the blood emerging from the vessel 6 once or repeatedly into the vessel 5 and thus to attain a multiple circulation of the blood.

The device described can also be used for blood transfusion in that the donors blood is freed from carbon dioxide by the oxygen or ozone treatment, and at the same time is irradiated with ultraviolet rays and, if necessary, sterilized.

While Fig. 1 shows diagrammatically the in ection of purified blood plasma introduced into the device, or of blood supplied directly from a blood donor, Fig. 2 shows how the patients blood can be passed in a direct c1rculation through one of the devices. By means of the second device the same patient may receive additionally a transfusion of a donors blood, as indicated in dotted lines.

Into the socket 8 of the vessel 5 additionally a glass bead filter is built which always generates foam bubbles of equal size with very thin walls and of predetermined size, whereby a practically complete ultraviolet irradia- While I have herein described and illustrated in the accompanying drawings what may be considered a typical and particularly useful example of my said invention, I wish it to be understood that I do not limit myself to the particular details and dimensions described and illustrated, for obvious modifications will occur to a person skilled in the art.

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What I claim as my invention and desire to secure by Letters Patent, is:

1. Apparatus for the saturation of blood with oxygen, comprising two vessels placed side by side and having their upper ends joined by a sloping plate, means for introducing untreated blood and oxygen into one of said vessels, and a narrow vertical tube arranged in said one vessel and adapted to receive through its lower end the untreated blood and oxygen whereby blood foam forms in said tube and is raised therein by the oxygen in the form of bubbles with thin walls, said tube penetrating the sloping plate and extending thereabove whereby the blood foam emerging from the upper end of the tube flows across the sloping plate in the form of a film into the other vessel where .it collapses.

2. Apparatus for the saturation of blood with oxygen, comprising two vessels placed side by side and having their upper ends joined by a sloping plate, means for introducing untreated blood and oxygen into one of said vessels, a narrow vertical tube arranged in said one vessel and adapted to receive through its lower end the untreated blood and oxygen whereby blood foam forms in said tube and is raised therein by the oxygen in the form of bubbles with thin walls, said tube penetrating the sloping plate and extending thereabove whereby the blood foam emerging from the upper end of the tube flows across the sloping plate in the form of a film into the other vessel where it collapses, and inlets at the upper introducing untreated blood and oxygen into one of said vessels, a narrow vertical tube arranged in said one vessel and adapted to receive through its lower end the untreated blood and oxygen whereby blood foam forms in said tube and is raised therein by the oxygen in the form of bubbles with thin walls, said tube penetrating the sloping plate and extending thereabove whereby the blood foam emerging from the upper end of the tube flows across the sloping plate in the form of a film into the other vessel where it collapses, inlets at the upper end of the apparatus for passing oxygen against said blood foam, a hood closing the upper ends of both vessels, and a quartz low pressure burner below said hood for the irradiation of the film of blood foam flowing across the sloping plate.

References Cited in the file of this patent UNITED STATES PATENTS 1,118,006 Henriet a1. Nov. 24, 1914 1,683,877 Edblom et al Sept. 11, 1928 2,309,124 Knott Jan. 26, 1943 

1. APPARATUS FOR THE SATURATION OF BLOOD WITH OXYGEN. COMPRISING TWO VESSELS PLACED SIDE BY SIDE AND HAVING THEIR UPPER ENDS JOINED BY A SLOPING PLATE, MEANS FOR INTRODUCING UNTREATED BLOOD AND OXYGEN INTO ONE OF SAID VESSELS, AND A NARROW VERTICAL TUBE ARRANGED IN SAID ONE VESSEL AND ADAPTED TO RECEIVE THROUGH ITS LOWER END THE UNTREATED BLOOD AND OXYGEN WHEREBY BLOOD FOAM FORMS IN SAID TUBE AND IS RAISED THEREIN BY THE OXYGEN IN THE FORM OF BUBBLES WITH THIN WALLS, SAID TUBE PENETRATING THE SLOPING PLATE AND EXTENDING THEREABOVE WHEREBY THE BLOOD FOAM EMERGING FROM THE UPPER END OF THE TUBE 